Life Sciences Research for Lifelong Health

Marc Veldhoen

Research Summary

Epithelial barrier sites such as the skin, respiratory and gastrointestinal tract, form a physical interface between our bodies and external environments. In addition to creating a physical impediment to pathogens, epithelial barriers include a diverse mix of immune cells, forming a first line of defence against invading pathogens.

immune systemsOur laboratory studies the role that cells of the immune system play at the initiation, modulation and resolution of immune responses at epithelial barrier sites. These studies provide insights into the mechanisms that control the maintenance of a resident population of micro-organisms, promoting healthy living, and the prevention of undesirable immune responses that may result in chronic infections, allergies, autoimmunity and an increased risk of cancer.

A specialised subset of white blood cells, the intra-epithelial lymphocytes (IELs), reside just beneath the epithelial barrier of skin and intestine. They are positioned to be the first members of the immune system to interact with, and respond to, microbial populations. In addition, they help maintain a physical barrier.

Our group had demonstrated that the AhR, a receptor molecule expressed in IELs, is a crucial component for the maintenance of the IEL populations in skin and gut. This demonstrates the important roles AhR play in maintaining the physical and immunological barriers that contribute to our lifelong health and well-being.

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Latest Publications

Tbet or Continued RORγt Expression Is Not Required for Th17-Associated Immunopathology.

Brucklacher-Waldert V, Ferreira C, Innocentin S

Journal of immunology (Baltimore, Md. : 1950)
1550-6606: (2016)

PMID: 27183623

Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.

Barros-Martins J, Schmolka N, Fontinha D

Journal of immunology (Baltimore, Md. : 1950)
1550-6606: (2016)

PMID: 26994218

Inflammation-induced formation of fat-associated lymphoid clusters.

Bénézech C, Luu NT, Walker JA

Nature immunology
1529-2916: (2015)

PMID: 26147686

Influence of nutrient-derived metabolites on lymphocyte immunity.

Veldhoen M, Ferreira C

Nature medicine
1546-170X: (2015)

PMID: 26121194

Helsinki alert of biodiversity and health.

von Hertzen L, Beutler B, Bienenstock J

Annals of medicine
1365-2060:1-8 (2015)

PMID: 25904094

Accumulation of an Endogenous Tryptophan-Derived Metabolite in Colorectal and Breast Cancers.

Puccetti P, Fallarino F, Italiano A

PloS one
10 1932-6203:e0122046 (0)

PMID: 25881064

Autophagy Controls Acquisition of Aging Features in Macrophages.

Stranks AJ, Hansen AL, Panse I

Journal of innate immunity
1662-8128: (2015)

PMID: 25764971

Feeding immunity: skepticism, delicacies and delights.

Veldhoen M, Veiga-Fernandes H

Nature immunology
16 1529-2916:215-219 (2015)

PMID: 25689432

CD28 expression is required after T cell priming for helper T cell responses and protective immunity to infection.

Linterman MA,Denton AE,Divekar DP,Zvetkova I,Kane L,Ferreira C,Veldhoen M,Clare S,Dougan G,Espeli M,Smith KG

3 2050-084X: (2014)

PMID: 25347065

Cellular Plasticity of CD4+ T Cells in the Intestine.

V Brucklacher-Waldert, EJ Carr, MA Linterman

Frontiers in immunology
5 1664-3224:488 (2014)

PMID: 25339956