Life Sciences Research for Lifelong Health
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Anita Chandra

Anita is a medic who obtained her primary medical degree from the University of Cambridge in 1998.  Following general medical training where she obtained membership of the Royal College of Physicians (MRCP), she commenced her training in Clinical Immunology, initially in Newcastle upon Tyne and soon thereafter, at Addenbrooke’s hospital in Cambridge. She subsequently obtained her Fellowship of the Royal College of Pathologists (FRCPath) and currently works as an Honorary Consultant at Addenbrooke’s hospital in Clinical Immunology. Her clinical interests involve the management and care of patients with primary and secondary immunodeficiency.

Anita obtained her PhD from the University of Cambridge following work on B cell biology and antibody diversification in the Laboratory of Molecular Biology under the supervision of Professor Michael Neuberger and Dr Cristina Rada. She is currently working as a Wellcome Trust funded Postdoctoral Clinical Fellow in the Okkenhaug lab, focusing on the role of PI3Ks in human and murine immunity and susceptibility to infections. She has a particular interest in a group of patients with an activating mutation in PI3K delta (APDS) and will be complementing basic mechanistic research in this area with clinical trials using selective PI3K delta inhibitors in patients.

01223 496388

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Latest Publications

Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy.

Okkenhaug K, Graupera M, Vanhaesebroeck B

Cancer discovery
2159-8290: (2016)

PMID: 27655435

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Eil R, Vodnala SK, Clever D

Nature
537 1476-4687:539-543 (2016)

PMID: 27626381

PI3Kδ and primary immunodeficiencies.

Lucas CL, Chandra A, Nejentsev S

Nature reviews. Immunology
1474-1741: (2016)

PMID: 27616589

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.

Coulter TI, Chandra A, Bacon CM

The Journal of allergy and clinical immunology
1097-6825: (2016)

PMID: 27555459

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.

Roychoudhuri R, Clever D, Li P

Nature immunology
1529-2916: (2016)

PMID: 27158840

The transcription factor BACH2 promotes tumor immunosuppression.

Roychoudhuri R, Eil RL, Clever D

The Journal of clinical investigation
1558-8238: (2016)

PMID: 26731475

Oncogenic PI3Kα promotes multipotency in breast epithelial cells.

Okkenhaug K, Roychoudhuri R

Science signaling
8 1937-9145:pe3 (2015)

PMID: 26535006

PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL).

Okkenhaug K, Burger JA

Current topics in microbiology and immunology
393 0070-217X:123-42 (2016)

PMID: 26350103

Editorial: Lipid Signaling in T Cell Development and Function.

Sauer K, Okkenhaug K

Frontiers in immunology
6 1664-3224:410 (2015)

PMID: 26322043

PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes.

Pearce VQ, Bouabe H, MacQueen AR

Journal of immunology (Baltimore, Md. : 1950)
1550-6606: (2015)

PMID: 26311905