Life Sciences Research for Lifelong Health
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Ee Lyn Lim

Lyn graduated from the University of Oxford in 2012 with an MBiochem in Molecular and Cellular Biochemistry. As part of her Masters’ year she spent 5 months in Caltech, California, where she worked on oncogenic microRNAs in leukaemia. Lyn’s current project as a PhD student at the Babraham Institute investigates the role of the PI3K isoform p110δ in tumour immune responses.

Latest Publications

Targeting PI3K in Cancer: Impact on Tumor Cells, Their Protective Stroma, Angiogenesis, and Immunotherapy.

Okkenhaug K, Graupera M, Vanhaesebroeck B

Cancer discovery
2159-8290: (2016)

PMID: 27655435

Ionic immune suppression within the tumour microenvironment limits T cell effector function.

Eil R, Vodnala SK, Clever D

Nature
537 1476-4687:539-543 (2016)

PMID: 27626381

PI3Kδ and primary immunodeficiencies.

Lucas CL, Chandra A, Nejentsev S

Nature reviews. Immunology
1474-1741: (2016)

PMID: 27616589

Clinical spectrum and features of activated phosphoinositide 3-kinase δ syndrome: A large patient cohort study.

Coulter TI, Chandra A, Bacon CM

The Journal of allergy and clinical immunology
1097-6825: (2016)

PMID: 27555459

BACH2 regulates CD8(+) T cell differentiation by controlling access of AP-1 factors to enhancers.

Roychoudhuri R, Clever D, Li P

Nature immunology
1529-2916: (2016)

PMID: 27158840

The transcription factor BACH2 promotes tumor immunosuppression.

Roychoudhuri R, Eil RL, Clever D

The Journal of clinical investigation
1558-8238: (2016)

PMID: 26731475

Oncogenic PI3Kα promotes multipotency in breast epithelial cells.

Okkenhaug K, Roychoudhuri R

Science signaling
8 1937-9145:pe3 (2015)

PMID: 26535006

PI3K Signaling in Normal B Cells and Chronic Lymphocytic Leukemia (CLL).

Okkenhaug K, Burger JA

Current topics in microbiology and immunology
393 0070-217X:123-42 (2016)

PMID: 26350103

Editorial: Lipid Signaling in T Cell Development and Function.

Sauer K, Okkenhaug K

Frontiers in immunology
6 1664-3224:410 (2015)

PMID: 26322043

PI3Kδ Regulates the Magnitude of CD8+ T Cell Responses after Challenge with Listeria monocytogenes.

Pearce VQ, Bouabe H, MacQueen AR

Journal of immunology (Baltimore, Md. : 1950)
1550-6606: (2015)

PMID: 26311905