Life Sciences Research for Lifelong Health

Geoff Butcher

Research Summary

In a healthy individual it is critically important that the number of mature T and B lymphocytes is maintained at a steady level. This process is termed lymphocyte homeostasis. The generation of new lymphocytes from precursor cells in the bone marrow and thymus is balanced by the loss of mature cells from peripheral compartments of the body.

Sometimes numbers of lymphocytes can increase dramatically, for example during infections. Once the infection has been successfully defeated by an immune response, lymphocyte numbers return to a normal level. The importance of maintaining lymphocyte homeostasis is evident from several immune diseases associated with having too few or too many lymphocytes. The regulation of lymphocyte survival vs. programmed cell death (apoptosis) is therefore essential to the survival of the healthy organism.

We are studying a family of signalling molecules called GTPases of the Immunity Associated Protein family (GIMAPs), which may play a part in the maintenance of lymphocyte populations.
 

Group Members

Latest Publications

Survival of mature T cells in the periphery is intrinsically dependent on GIMAP1 in mice.

Datta P, Webb LM, Avdo I

European journal of immunology
1521-4141: (2016)

PMID: 27792288

GIMAP1 Is Essential for the Survival of Naive and Activated B Cells In Vivo.

Webb LM, Datta P, Bell SE

Journal of immunology (Baltimore, Md. : 1950)
1550-6606: (2015)

PMID: 26621859

Generation and characterisation of mice deficient in the multi-GTPase domain containing protein, GIMAP8.

Webb LM, Pascall JC, Hepburn L

PloS one
9 1932-6203:e110294 (2014)

PMID: 25329815

The miR-155-PU.1 axis acts on Pax5 to enable efficient terminal B cell differentiation.

Lu D, Nakagawa R, Lazzaro S

The Journal of experimental medicine
211 1540-9538:2183-98 (2014)

PMID: 25288398

Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse.

Yano K, Carter C, Yoshida N

European journal of immunology
44 1521-4141:561-72 (2014)

PMID: 24510501

The autoimmunity-related GIMAP5 GTPase is a lysosome-associated protein.

VW Wong, AE Saunders, A Hutchings

Self/nonself
1 3:259-268 (2010)

DOI: 10.4161/self.1.3.12819

PMID: 21487483