Life Sciences Research for Lifelong Health

Lymphocyte Signalling

Lymphocyte Signalling

The study of the processes that regulate the development, survival and function of white blood cells

The primary goals of the immune system are to protect the body against invading pathogens and prevent subsequent infection. This powerful system must be carefully balanced to ensure that it does not destroy the body it has evolved to protect. We use a multidisciplinary approach to investigate the receptors and pathways that regulate lymphocyte development and activation.

Lymph nodeWhat are lymphocytes?

Lymphocytes are a subset of white blood cells and can be divided into three main classes.

T cells, which develop in the thymus mediate cell-mediated immunity and help B cells generate antibodies;
B cells, which develop in the bone marrow and mediate humoral immunity by secreting antibodies;
Innate lymphocytes, which do not express T cell or B cell receptors for antigen, but play essential roles in an infection.

Each class of lymphocyte functionally interacts with the others to mount an immune response.

Treg Lymph nodeWhy are they important?

The primary goals of the immune system are to protect the body against invading pathogens and prevent subsequent infection. This powerful system must be carefully balanced to ensure that it does not destroy the body it has evolved to protect.

A greater understanding of immunity is central to the goal of promoting a healthier lifespan. We aim to understand the processes that regulate the development, survival and function of lymphocytes.

This is essential to improve vaccines, combat autoimmune diseases, develop immunotherapy or improve the efficiency of organ transplantation.

Germinal CentreWhat is our research?

We are studying how, with advancing age, the size of the germinal centre response and the efficacy of vaccinations diminish. We aim to understand the roles of RNA binding proteins in lymphocyte development and activation throughout life.

We are investigating the basic biology of PI3K and applying this knowledge to understand immunity and immunodeficiency. We study the mechanisms that control the interaction of lymphocytes and epithelial cells and the mechanisms by which transcription factors regulate immune function .


Immunology Feature

Our 2016 Annual Research Report includes feature articles highligting some of the themes that each research programme is working on.

The Immunology feature "Checks and balances in immune system development", looks at the role of RNA binding proteins in regulating the behaviour of the cells in our immune system.



"In 1796, a doctor in rural Gloucestershire took pus from a cowpox lesion on a milkmaid’s hand to inoculate an eight-year-old boy against smallpox. More than 230 years after Edward Jenner’s pioneering vaccination, we still don’t fully understand how our immune system works..." continue reading

24/07/2017

Rahul Roychoudhuri awarded prestigious Lister Prize

Lister Fellowships are awarded to five young independent researchers each year

Lister Institute of Preventive Medicine selects Dr Roychoudhuri…


26/10/2016

Insights to real-life research

“A whirlwind week”

Teachers reflect on lab placements


20/10/2016

Michelle Linterman becomes an EMBO Young Investigator

Awards recognise world-class research potential

Programme provides financial and career support

 

Links

Research Impact

9 Industrial Research Collaborations

5 CASE PhD Studentships

11 Formal Industrial Consultancy Agreements

2 New IP Licence Agreements

Group Leaders