Life Sciences Research for Lifelong Health

Melanie Eckersley-Maslin

Short Biography:
 
2014 - current: Postdoctoral Research Fellow, Babraham Institute, Cambridge UK (funded by EMBO LT Fellowship and Marie Curie Individual Fellowship) and Sackler Research Fellow, Christ's College, The University of Cambridge www.christs.cam.ac.uk/content/dr-melanie-eckersley-maslin
2008-2014: PhD in Molecular Biology, The Watson School of Biological Sciences, Cold Spring Harbor Laboratory, USA
2004-2007: Bachelor of Advanced Science (Honours, University Medal), The University of Sydney, Australia
 
Research Interests:
 
My research passion surrounds the very early stages of mammalian embryonic development, one of the most dramatic chromatin and epigenetic transformations in an organism's life. Following fertilisation, the embryonic genome must be correctly remodelled and transcriptionally activated to produce a totipotent embryo. My research aims to understand the epigenetic contribution of these developmental events, including how zygotic genome activation is regulated at the molecular level, and the contribution of epigenetic and transcriptional heterogeneity between single cells in cell fate decisions.



Latest Publications

Tracking the embryonic stem cell transition from ground state pluripotency.

Kalkan T, Olova N, Roode M

Development (Cambridge, England)
1477-9129: (2017)

PMID: 28174249

Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming.

Milagre I, Stubbs TM, King MR

Cell reports
18 2211-1247:1079-1089 (2017)

PMID: 28147265

A Hox-Embedded Long Noncoding RNA: Is It All Hot Air?

Selleri L, Bartolomei MS, Bickmore WA

PLoS genetics
12 1553-7404:e1006485 (2016)

PMID: 27977680

Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase.

Stepper P, Kungulovski G, Jurkowska RZ

Nucleic acids research
1362-4962: (2016)

PMID: 27899645

The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy.

Thienpont B, Aronsen JM, Robinson EL

The Journal of clinical investigation
1558-8238: (2016)

PMID: 27893464

Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.

Hore TA, von Meyenn F, Ravichandran M

Proceedings of the National Academy of Sciences of the United States of America
1091-6490: (2016)

PMID: 27729528

Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification.

von Meyenn F, Berrens RV, Andrews S

Developmental cell
39 1878-1551:104-115 (2016)

PMID: 27728778

MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs.

Eckersley-Maslin MA, Svensson V, Krueger C

Cell reports
17 2211-1247:179-92 (2016)

PMID: 27681430

In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine.

Iurlaro M, McInroy GR, Burgess HE

Genome biology
17 1474-760X:141 (2016)

PMID: 27356509

Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity.

Clark SJ, Lee HJ, Smallwood SA

Genome biology
17 1474-760X:72 (2016)

PMID: 27091476