Life Sciences Research for Lifelong Health

Melanie Eckersley-Maslin

Short Biography:
 
2014 - current: Postdoctoral Research Fellow, Babraham Institute, Cambridge UK (funded by EMBO LT Fellowship and Marie Curie Individual Fellowship) and Sackler Research Fellow, Christ's College, The University of Cambridge www.christs.cam.ac.uk/content/dr-melanie-eckersley-maslin
2008-2014: PhD in Molecular Biology, The Watson School of Biological Sciences, Cold Spring Harbor Laboratory, USA
2004-2007: Bachelor of Advanced Science (Honours, University Medal), The University of Sydney, Australia
 
Research Interests:
 
My research passion surrounds the very early stages of mammalian embryonic development, one of the most dramatic chromatin and epigenetic transformations in an organism's life. Following fertilisation, the embryonic genome must be correctly remodelled and transcriptionally activated to produce a totipotent embryo. My research aims to understand the epigenetic contribution of these developmental events, including how zygotic genome activation is regulated at the molecular level, and the contribution of epigenetic and transcriptional heterogeneity between single cells in cell fate decisions.



Latest Publications

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

Kirschner K, Chandra T, Kiselev V

Cell reports
19 2211-1247:1503-1511 (2017)

PMID: 28538171

A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming.

Vasiliauskaitė L, Vitsios D, Berrens RV

Nature structural & molecular biology
1545-9985: (2017)

PMID: 28530707

Multi-tissue DNA methylation age predictor in mouse.

Stubbs TM, Bonder MJ, Stark AK

Genome biology
18 1474-760X:68 (2017)

PMID: 28399939

DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning.

Angermueller C, Lee HJ, Reik W

Genome biology
18 1474-760X:67 (2017)

PMID: 28395661

SC3: consensus clustering of single-cell RNA-seq data.

Kiselev VY, Kirschner K, Schaub MT

Nature methods
1548-7105: (2017)

PMID: 28346451

DNA methylation homeostasis in human and mouse development.

Iurlaro M, von Meyenn F, Reik W

Current opinion in genetics & development
43 1879-0380:101-109 (2017)

PMID: 28260631

The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice.

Langie SA, Cameron KM, Ficz G

Genes
8 : (2017)

PMID: 28218666

Tracking the embryonic stem cell transition from ground state pluripotency.

Kalkan T, Olova N, Roode M

Development (Cambridge, England)
1477-9129: (2017)

PMID: 28174249

Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming.

Milagre I, Stubbs TM, King MR

Cell reports
18 2211-1247:1079-1089 (2017)

PMID: 28147265

A Hox-Embedded Long Noncoding RNA: Is It All Hot Air?

Selleri L, Bartolomei MS, Bickmore WA

PLoS genetics
12 1553-7404:e1006485 (2016)

PMID: 27977680