Thomas Stubbs2014 - present – PhD candidate in Molecular Biology, Babraham Institute, Cambridge, UK (under the supervision of Professor Wolf Reik).
2013-2014 – Master’s degree in Research (MRes), University of Cambridge, UK.
2009-2013 – Master’s degree in Molecular and Cellular Biochemistry (MBiochem), University of Oxford, UK (First-class honours).
My research interest is centered on the most prolific of all diseases: ageing. Why do organisms age? What does ageing mean at a cellular and molecular level? In particular, I am interested in the epigenetic changes that characterise ageing and how these changes can be used not only to study but also to halt or reverse aspects of ageing. My research is focused on understanding the dynamics of DNA methylation with age and how we can use these dynamics to predict biological age in the mouse. This readout of biological age in the mouse will aid the speed with which ageing can be studied in mammalian systems.
Iurlaro M, von Meyenn F, Reik W
Current opinion in genetics & development
43 1879-0380:101-109 (2017)
Langie SA, Cameron KM, Ficz G
8 : (2017)
Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq).
Clark SJ, Smallwood SA, Lee HJ
12 1750-2799:534-547 (2017)
Kalkan T, Olova N, Roode M
Development (Cambridge, England)
Milagre I, Stubbs TM, King MR
18 2211-1247:1079-1089 (2017)
Selleri L, Bartolomei MS, Bickmore WA
12 1553-7404:e1006485 (2016)
Stepper P, Kungulovski G, Jurkowska RZ
Nucleic acids research
Thienpont B, Aronsen JM, Robinson EL
The Journal of clinical investigation
Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.
Hore TA, von Meyenn F, Ravichandran M
Proceedings of the National Academy of Sciences of the United States of America
Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification.
von Meyenn F, Berrens RV, Andrews S
39 1878-1551:104-115 (2016)
Eckersley-Maslin MA, Svensson V, Krueger C
17 2211-1247:179-92 (2016)
Iurlaro M, McInroy GR, Burgess HE
17 1474-760X:141 (2016)