Rebecca BerrensShort Biography
2013 - current: PhD student at Cambridge University, Babraham Institute (Funded by Gates Cambridge scholarship)
2010 - 2012: Master in Molecular Biotechnology at Heidelberg University
2007 - 2010: Bachelor in Molecular Cell Biology at Heidelberg University
Research Interests and Activities
I am interested in transposon regulation and its role in epigenetic reprogramming during early embryonic development in mammals.
Transposons are known to be highly guarded by DNA methylation in somatic cells, though histone modifications and small RNAs have also been found to play a role in keeping these repeat elements in check.
My work focuses on the effect of the genome wide erasure of epigenetic marks in the early embryo, on transposon activity. Specifically, the dynamics and interplay between DNA methylation, histone modifications and, my main area of interest- small RNAs, which lead to the silencing of transposons.
Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq).
Clark SJ, Smallwood SA, Lee HJ
12 1750-2799:534-547 (2017)
Kalkan T, Olova N, Roode M
Development (Cambridge, England)
Milagre I, Stubbs TM, King MR
18 2211-1247:1079-1089 (2017)
Selleri L, Bartolomei MS, Bickmore WA
12 1553-7404:e1006485 (2016)
Stepper P, Kungulovski G, Jurkowska RZ
Nucleic acids research
Thienpont B, Aronsen JM, Robinson EL
The Journal of clinical investigation
Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.
Hore TA, von Meyenn F, Ravichandran M
Proceedings of the National Academy of Sciences of the United States of America
Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification.
von Meyenn F, Berrens RV, Andrews S
39 1878-1551:104-115 (2016)
Eckersley-Maslin MA, Svensson V, Krueger C
17 2211-1247:179-92 (2016)
Iurlaro M, McInroy GR, Burgess HE
17 1474-760X:141 (2016)
Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.
von Meyenn F, Iurlaro M, Habibi E
Clark SJ, Lee HJ, Smallwood SA
17 1474-760X:72 (2016)