Life Sciences Research for Lifelong Health

Solenn Patalano

Short Biography
•       2011-current: Post-Doctoral Research Associate, Babraham Institute, Cambridge. (Funded by Wellcome Trust grant)
•       2009-2010: Research Assistant, Institute of Zoology, London (Funded by NERC grant)
•       2008: European PhD in Molecular, Cellular and Developmental Biology, CRG, Barcelona/ Nice. (Fellowship from Spanish Government, EUROBIO recognition for mobility and adaptability in new working environment)


Research Interests and Activities
“Sociogenomic” is a very recent but active field to study social organisation in molecular term. My current research seeks to understand the epigenetic mechanisms underlying genomic regulation and variability across individuals in the context of a social organisation.

My activities focus on the exploration of the dynamic of DNA methylation for the neuronal and behavioural plasticity. I am using two social insect models (the Polistes paper wasp and the Dinoponera Dinosaur ant). Social insects and particularly those organized into simple societies (with few individuals per colony) are interesting groups which retain some trait from their solitary ancestors like flexibility in reproduction behaviour. We are using this natural plasticity of insect societies, their ordinary range of behaviours and their genomes’ simplicity to investigate the mechanisms of the maintenance of phenotypic plasticity.

Latest Publications

A Hox-Embedded Long Noncoding RNA: Is It All Hot Air?

Selleri L, Bartolomei MS, Bickmore WA

PLoS genetics
12 1553-7404:e1006485 (2016)

PMID: 27977680

Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase.

Stepper P, Kungulovski G, Jurkowska RZ

Nucleic acids research
1362-4962: (2016)

PMID: 27899645

The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy.

Thienpont B, Aronsen JM, Robinson EL

The Journal of clinical investigation
1558-8238: (2016)

PMID: 27893464

Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.

Hore TA, von Meyenn F, Ravichandran M

Proceedings of the National Academy of Sciences of the United States of America
1091-6490: (2016)

PMID: 27729528

Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification.

von Meyenn F, Berrens RV, Andrews S

Developmental cell
39 1878-1551:104-115 (2016)

PMID: 27728778

MERVL/Zscan4 Network Activation Results in Transient Genome-wide DNA Demethylation of mESCs.

Eckersley-Maslin MA, Svensson V, Krueger C

Cell reports
17 2211-1247:179-92 (2016)

PMID: 27681430

In vivo genome-wide profiling reveals a tissue-specific role for 5-formylcytosine.

Iurlaro M, McInroy GR, Burgess HE

Genome biology
17 1474-760X:141 (2016)

PMID: 27356509

Single-cell epigenomics: powerful new methods for understanding gene regulation and cell identity.

Clark SJ, Lee HJ, Smallwood SA

Genome biology
17 1474-760X:72 (2016)

PMID: 27091476

Naive Pluripotent Stem Cells Derived Directly from Isolated Cells of the Human Inner Cell Mass.

Guo G, von Meyenn F, Santos F

Stem cell reports
2213-6711: (2016)

PMID: 26947977

Maternal DNA Methylation Regulates Early Trophoblast Development.

Branco MR, King M, Perez-Garcia V

Developmental cell
36 1878-1551:152-63 (2016)

PMID: 26812015

Parallel single-cell sequencing links transcriptional and epigenetic heterogeneity.

Angermueller C, Clark SJ, Lee HJ

Nature methods
1548-7105: (2016)

PMID: 26752769