Life Sciences Research for Lifelong Health

Solenn Patalano

Short Biography
•       2011-current: Post-Doctoral Research Associate, Babraham Institute, Cambridge. (Funded by Wellcome Trust grant)
•       2009-2010: Research Assistant, Institute of Zoology, London (Funded by NERC grant)
•       2008: European PhD in Molecular, Cellular and Developmental Biology, CRG, Barcelona/ Nice. (Fellowship from Spanish Government, EUROBIO recognition for mobility and adaptability in new working environment)

Research Interests and Activities
“Sociogenomic” is a very recent but active field to study social organisation in molecular term. My current research seeks to understand the epigenetic mechanisms underlying genomic regulation and variability across individuals in the context of a social organisation.

My activities focus on the exploration of the dynamic of DNA methylation for the neuronal and behavioural plasticity. I am using two social insect models (the Polistes paper wasp and the Dinoponera Dinosaur ant). Social insects and particularly those organized into simple societies (with few individuals per colony) are interesting groups which retain some trait from their solitary ancestors like flexibility in reproduction behaviour. We are using this natural plasticity of insect societies, their ordinary range of behaviours and their genomes’ simplicity to investigate the mechanisms of the maintenance of phenotypic plasticity.

Latest Publications

Multi-tissue DNA methylation age predictor in mouse.

Stubbs TM, Bonder MJ, Stark AK

Genome biology
18 1474-760X:68 (2017)

PMID: 28399939

DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning.

Angermueller C, Lee HJ, Reik W

Genome biology
18 1474-760X:67 (2017)

PMID: 28395661

SC3: consensus clustering of single-cell RNA-seq data.

Kiselev VY, Kirschner K, Schaub MT

Nature methods
1548-7105: (2017)

PMID: 28346451

DNA methylation homeostasis in human and mouse development.

Iurlaro M, von Meyenn F, Reik W

Current opinion in genetics & development
43 1879-0380:101-109 (2017)

PMID: 28260631

The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice.

Langie SA, Cameron KM, Ficz G

8 : (2017)

PMID: 28218666

Tracking the embryonic stem cell transition from ground state pluripotency.

Kalkan T, Olova N, Roode M

Development (Cambridge, England)
1477-9129: (2017)

PMID: 28174249

Gender Differences in Global but Not Targeted Demethylation in iPSC Reprogramming.

Milagre I, Stubbs TM, King MR

Cell reports
18 2211-1247:1079-1089 (2017)

PMID: 28147265

A Hox-Embedded Long Noncoding RNA: Is It All Hot Air?

Selleri L, Bartolomei MS, Bickmore WA

PLoS genetics
12 1553-7404:e1006485 (2016)

PMID: 27977680

Efficient targeted DNA methylation with chimeric dCas9-Dnmt3a-Dnmt3L methyltransferase.

Stepper P, Kungulovski G, Jurkowska RZ

Nucleic acids research
1362-4962: (2016)

PMID: 27899645

The H3K9 dimethyltransferases EHMT1/2 protect against pathological cardiac hypertrophy.

Thienpont B, Aronsen JM, Robinson EL

The Journal of clinical investigation
1558-8238: (2016)

PMID: 27893464