Christel KruegerShort biography
- 2005 - current: Post-Doctoral Research Associate, Babraham Institute, Cambridge, UK (funded by personal fellowships from EMBO, DFG and CTR, as well as by BBSRC and Wellcome Trust grants)
- 2001 - 2004: PhD in Biology, Friedrich-Alexander Universitaet Erlangen, Germany (State of Bavaria Fellowship)
Research Interests and Activities
I have a fascination with life, especially with the beginning of it. When the parental gametes meet to form a zygote, a new organism comes into being. A number of biologically drastic measures are taken both before and after fertilisation to turn the old generation into a new one: Not only is the age of the parental cells set to zero, but also are two highly specialised cells (the gametes) turned into one all-rounder (the totipotent zygote). Being a molecular biologist, I’m interested in how this is brought about on a molecular level, and currently I’m studying a potential mechanism of bringing about totipotency.
Genome-wide base-resolution mapping of DNA methylation in single cells using single-cell bisulfite sequencing (scBS-seq).
Clark SJ, Smallwood SA, Lee HJ
12 1750-2799:534-547 (2017)
Kalkan T, Olova N, Roode M
Development (Cambridge, England)
Milagre I, Stubbs TM, King MR
18 2211-1247:1079-1089 (2017)
Selleri L, Bartolomei MS, Bickmore WA
12 1553-7404:e1006485 (2016)
Stepper P, Kungulovski G, Jurkowska RZ
Nucleic acids research
Thienpont B, Aronsen JM, Robinson EL
The Journal of clinical investigation
Retinol and ascorbate drive erasure of epigenetic memory and enhance reprogramming to naïve pluripotency by complementary mechanisms.
Hore TA, von Meyenn F, Ravichandran M
Proceedings of the National Academy of Sciences of the United States of America
Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification.
von Meyenn F, Berrens RV, Andrews S
39 1878-1551:104-115 (2016)
Eckersley-Maslin MA, Svensson V, Krueger C
17 2211-1247:179-92 (2016)
Iurlaro M, McInroy GR, Burgess HE
17 1474-760X:141 (2016)
Impairment of DNA Methylation Maintenance Is the Main Cause of Global Demethylation in Naive Embryonic Stem Cells.
von Meyenn F, Iurlaro M, Habibi E
Clark SJ, Lee HJ, Smallwood SA
17 1474-760X:72 (2016)