Life Sciences Research for Lifelong Health

Christel Krueger

Short biography
  • 2005 - current: Post-Doctoral Research Associate, Babraham Institute, Cambridge, UK (funded by personal fellowships from EMBO, DFG and CTR, as well as by BBSRC and Wellcome Trust grants)
  • 2001 - 2004: PhD in Biology, Friedrich-Alexander Universitaet Erlangen, Germany (State of Bavaria Fellowship)
 
Research Interests and Activities
I have a fascination with life, especially with the beginning of it. When the parental gametes meet to form a zygote, a new organism comes into being. A number of biologically drastic measures are taken both before and after fertilisation to turn the old generation into a new one: Not only is the age of the parental cells set to zero, but also are two highly specialised cells (the gametes) turned into one all-rounder (the totipotent zygote). Being a molecular biologist, I’m interested in how this is brought about on a molecular level, and currently I’m studying a potential mechanism of bringing about totipotency.

Latest Publications

Single-Cell Landscape of Transcriptional Heterogeneity and Cell Fate Decisions during Mouse Early Gastrulation.

Mohammed H, Hernando-Herraez I, Savino A

Cell reports
20 2211-1247:1215-1228 (2017)

PMID: 28768204

Epigenetic resetting of human pluripotency.

Guo G, von Meyenn F, Rostovskaya M

Development (Cambridge, England)
144 1477-9129:2748-2763 (2017)

PMID: 28765214

Proliferation Drives Aging-Related Functional Decline in a Subpopulation of the Hematopoietic Stem Cell Compartment.

Kirschner K, Chandra T, Kiselev V

Cell reports
19 2211-1247:1503-1511 (2017)

PMID: 28538171

A MILI-independent piRNA biogenesis pathway empowers partial germline reprogramming.

Vasiliauskaitė L, Vitsios D, Berrens RV

Nature structural & molecular biology
1545-9985: (2017)

PMID: 28530707

Multi-tissue DNA methylation age predictor in mouse.

Stubbs TM, Bonder MJ, Stark AK

Genome biology
18 1474-760X:68 (2017)

PMID: 28399939

DeepCpG: accurate prediction of single-cell DNA methylation states using deep learning.

Angermueller C, Lee HJ, Reik W

Genome biology
18 1474-760X:67 (2017)

PMID: 28395661

SC3: consensus clustering of single-cell RNA-seq data.

Kiselev VY, Kirschner K, Schaub MT

Nature methods
1548-7105: (2017)

PMID: 28346451

DNA methylation homeostasis in human and mouse development.

Iurlaro M, von Meyenn F, Reik W

Current opinion in genetics & development
43 1879-0380:101-109 (2017)

PMID: 28260631

The Ageing Brain: Effects on DNA Repair and DNA Methylation in Mice.

Langie SA, Cameron KM, Ficz G

Genes
8 : (2017)

PMID: 28218666

Tracking the embryonic stem cell transition from ground state pluripotency.

Kalkan T, Olova N, Roode M

Development (Cambridge, England)
1477-9129: (2017)

PMID: 28174249