Life Sciences Research for Lifelong Health

Group Members

Our group is housed within a large open plan lab that is shared with all members of the Epigenetics Programme. The open setting establishes an exciting dynamic between research groups, often leading to collaborations, training in new methods and interesting discussions. Weekly departmental meetings and seminars reinforce these close interactions.

Outside of Epigenetics and Nuclear Dynamics, we collaborate closely with several groups within the Lymphocyte and Signalling Programmes, with a particular focus on potential interactions between signalling pathways and epigenetic processes. Our research also benefits greatly from the excellent facilities at the Babraham Institute, with state-of-the-art genomics, flow cytometry, imaging, mass spectrometry and bioinformatics.

​We maintain close links with the University of Cambridge, with affiliations at the WT-MRC Cambridge Stem Cell Institute ( and the Centre for Trophoblast Research ( Our group is also a member of the EpiGeneSys Network, which is focused on epigenetics and systems biology.

Peter Rugg-Gunn​Peter's Career

Peter joined the Babraham Institute in 2011 as a Wellcome Trust Research Career Development Fellow. Peter trained in the laboratories of Roger Pedersen (University of Cambridge) and Janet Rossant (The Hospital for Sick Children, Toronto) where he developed his interest in understanding the epigenetic regulation of stem cells and lineage specification.

Peter is also involved in the societal impact of stem cell research – most recently working with artists to generate a major exhibition that examines the complex ethical and social issues surrounding biotechnology.

Amanda Collier

Miss Charlene Fabian

Dr Clara Novo

Dr Peter Rugg-Gunn


Latest Publications

Derivation and Culture of Epiblast Stem Cell (EpiSC) Lines.

Rugg-Gunn P

Cold Spring Harbor protocols
2017 1559-6095:pdb.prot093971 (2017)

PMID: 28049783

Derivation and Culture of Extra-Embryonic Endoderm Stem Cell Lines.

Rugg-Gunn P

Cold Spring Harbor protocols
2017 1559-6095:pdb.prot093963 (2017)

PMID: 28049782

Crosstalk between pluripotency factors and higher-order chromatin organization.

Lopes Novo C, Rugg-Gunn PJ

Nucleus (Austin, Tex.)
1949-1042:0 (2016)

PMID: 27759487

Comparative Principles of DNA Methylation Reprogramming during Human and Mouse In Vitro Primordial Germ Cell Specification.

von Meyenn F, Berrens RV, Andrews S

Developmental cell
39 1878-1551:104-115 (2016)

PMID: 27728778

Chromatin organization in pluripotent cells: emerging approaches to study and disrupt function.

Lopes Novo C, Rugg-Gunn PJ

Briefings in functional genomics
2041-2657: (2015)

PMID: 26206085

Epigenetic features of the mouse trophoblast.

PJ Rugg-Gunn

Reproductive biomedicine online
25 1:21-30 (2012)

DOI: 10.1016/j.rbmo.2012.01.012

PMID: 22578826

Cell-surface proteomics identifies lineage-specific markers of embryo-derived stem cells.

PJ Rugg-Gunn, BJ Cox, F Lanner

Developmental cell
22 4:887-901 (2012)

DOI: 10.1016/j.devcel.2012.01.005

PMID: 22424930