Juan Rodriguez-MolinaEvery living creature on this planet is subject to the continuous process of aging. This natural process (albeit unpleasant and unforgiving) does not occur in all individuals in the same fashion. Why? Certainly, genetics play a major role, but can it fully explain how diverse the aging process is? How much of an organism's identity and fate is determined by its genetics vs. its experience? Can that experience somehow influence the life of future generations? Could it be, for example, that my upbringing in the Caribbean paradise of Puerto Rico will have a sunny effect on my children and grandchildren? Precise regulation of transcription (synthesis of RNA from DNA) is at the heart of how individuals respond to environmental and developmental cues. In the model organism Caenorhabditis elegans, as in many other animals, some regulatory states of transcription initially elicited in a parent can be inherited onto its progeny through mechanisms that remain poorly understood.
Li C, Casanueva O
Essays in biochemistry
60 1744-1358:191-202 (2016)
Niche-associated activation of rac promotes the asymmetric division of Drosophila female germline stem cells.
W Lu, MO Casanueva, AP Mahowald
10 7:e1001357 (2012)
MO Casanueva, A Burga, B Lehner
Science (New York, N.Y.)
335 6064:82-5 (2012)
A Burga, MO Casanueva, B Lehner
480 7376:250-3 (2011)
Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells.
SM Garcia, MO Casanueva, MC Silva
Genes & development
21 22:3006-16 (2007)
Germline stem cell number in the Drosophila ovary is regulated by redundant mechanisms that control Dpp signaling.
MO Casanueva, EL Ferguson
Development (Cambridge, England)
131 9:1881-90 (2004)
At least two receptors of asymmetric acetylcholinesterase are present at the synaptic basal lamina of Torpedo electric organ.
OI Casanueva, P Deprez, T García-Huidobro
Biochemical and biophysical research communications
250 2:312-7 (1998)
A major portion of synaptic basal lamina acetylcholinesterase is detached by high salt- and heparin-containing buffers from rat diaphragm muscle and Torpedo electric organ.
Casanueva OI, García-Huidobro T, Campos EO
The Journal of biological chemistry
273 0021-9258:4258-65 (1998)
Acetylcholinesterase accelerates assembly of amyloid-beta-peptides into Alzheimer's fibrils: possible role of the peripheral site of the enzyme.
NC Inestrosa, A Alvarez, CA Pérez
16 4:881-91 (1996)