Life Sciences Research for Lifelong Health
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Juan Rodriguez-Molina

Every living creature on this planet is subject to the continuous process of aging. This natural process (albeit unpleasant and unforgiving) does not occur in all individuals in the same fashion. Why? Certainly, genetics play a major role, but can it fully explain how diverse the aging process is? How much of an organism's identity and fate is determined by its genetics vs. its experience? Can that experience somehow influence the life of future generations? Could it be, for example, that my upbringing in the Caribbean paradise of Puerto Rico will have a sunny effect on my children and grandchildren? Precise regulation of transcription (synthesis of RNA from DNA) is at the heart of how individuals respond to environmental and developmental cues. In the model organism Caenorhabditis elegans, as in many other animals, some regulatory states of transcription initially elicited in a parent can be inherited onto its progeny through mechanisms that remain poorly understood.

Latest Publications

Epigenetic inheritance of proteostasis and ageing.

Li C, Casanueva O

Essays in biochemistry
60 1744-1358:191-202 (2016)

PMID: 27744335

Fitness trade-offs and environmentally induced mutation buffering in isogenic C. elegans.

MO Casanueva, A Burga, B Lehner

Science (New York, N.Y.)
335 6064:82-5 (2012)

DOI: 10.1126/science.1213491

PMID: 22174126

Neuronal signaling modulates protein homeostasis in Caenorhabditis elegans post-synaptic muscle cells.

SM Garcia, MO Casanueva, MC Silva

Genes & development
21 22:3006-16 (2007)

DOI: 10.1101/gad.1575307

PMID: 18006691

Germline stem cell number in the Drosophila ovary is regulated by redundant mechanisms that control Dpp signaling.

MO Casanueva, EL Ferguson

Development (Cambridge, England)
131 9:1881-90 (2004)

DOI: 10.1242/dev.01076

PMID: 15105369

At least two receptors of asymmetric acetylcholinesterase are present at the synaptic basal lamina of Torpedo electric organ.

OI Casanueva, P Deprez, T García-Huidobro

Biochemical and biophysical research communications
250 2:312-7 (1998)

DOI: 10.1006/bbrc.1998.9303

PMID: 9753626