Life Sciences Research for Lifelong Health

Myriam Hemberger

Research Summary

The focus of our work is on the establishment, maintenance and differentiation of trophoblast cells leading to formation of a functional placenta. The placenta is the defining organ of most mammals, providing a nutritive conduit that is crucial for all embryonic development to occur. Trophoblast cells are the major building blocks of the developing placenta. They are the first cell type to arise very early in development when they are set apart from cells giving rise to the embryo itself. The various functions of trophoblast cells early in development are vital for reproductive success, as they lay the foundations for a normal pregnancy and healthy foetus later on. A better understanding of the mechanisms underlying these early events will be critical to develop better screens and therapeutic avenues for pregnancy complications.
 
We are in particular interested in how the early trophoblast niche is regulated by transcription factors and specific epigenetic modifiers to ensure normal development. Leading on from this, we also investigate how susceptible the trophoblast compartment is to perturbations by extrinsic factors that activate specific signalling cascades, including in the context of development in mothers of advanced age. For this we are taking a range of high-throughput epigenomic and transcriptomic approaches to study these early events in placental development.
 
Key among our tools is the use of murine trophoblast stem (TS) cells, which mimic many of the properties of the early placenta. Learning about the self-renewal mechanisms of TS cells, in comparison to embryonic stem (ES) cells, will help us uncover the fundamental principles of how the early placenta develops and is influenced by external factors, which may be predictive for life long physiology and health. These insights will also enable us to better understand the earliest steps in human placentation and to develop novel cellular research tools to study the underlying molecular processes.

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Latest Publications

From the stem of the placental tree: trophoblast stem cells and their progeny.

Latos PA, Hemberger M

Development (Cambridge, England)
143 1477-9129:3650-3660 (2016)

PMID: 27802134

What Is Trophoblast? A Combination of Criteria Define Human First-Trimester Trophoblast.

Lee CQ, Gardner L, Turco M

Stem cell reports
6 2213-6711:257-72 (2016)

PMID: 26862703

Maternal DNA Methylation Regulates Early Trophoblast Development.

Branco MR, King M, Perez-Garcia V

Developmental cell
36 1878-1551:152-63 (2016)

PMID: 26812015

ADP-ribosyltransferases Parp1 and Parp7 safeguard pluripotency of ES cells.

Roper SJ, Chrysanthou S, Senner CE

Nucleic acids research
42 1362-4962:8914-27 (2014)

PMID: 25034692

Derivation and maintenance of murine trophoblast stem cells under defined conditions.

Kubaczka C,Senner C,Arauzo-Bravo MJ,Sharma N,Kuckenberg P,Becker A,Zimmer A,Brustle O,Peitz M, M Hemberger,Schorle H

Stem cell reports
2 2213-6711:232-42 (2014)

PMID: 24527396

The H19 induction triggers trophoblast lineage commitment in mouse ES cells.

H Fujimori, H Mukai, Y Murakami

Biochemical and biophysical research communications
436 2:313-8 (2013)

DOI: 10.1016/j.bbrc.2013.05.100

PMID: 23743205