Life Sciences Research for Lifelong Health

RhoGEFs as signaling platforms of chemotactic GPCRs

Cancer cells and stroma cells in tumors secrete chemotactic agonists that exacerbate invasive behavior, promote tumor-induced angiogenesis, and recruit protumoral bone marrow-derived cells. In response to shallow gradients of chemotactic stimuli recognized by G protein-coupled receptors (GPCRs), Gbg-dependent effectors such as Phosphoinositide-3-kinases and Rac guanine nucleotide exchange factors, such as P-Rex1, contribute to the activation of Rho GTPases and their cytoskeletal-remodeling effectors. P-Rex1, as many other Rho guanine nucleotide exchange factors coexpressed in protumoral cells, is a multidomain protein that interacts with multiple regulators and upstream signaling partners. The role of P-Rex1 as a signaling platform of chemotactic GPCRs will be discussed based on its interactions with GPCRs, Gbg and the serine/threonine kinases mTOR and PKA. Overall, the proven relevance of multiple chemokines in oncogenic settings has pointed to RhoGEFs as potential pharmacologic targets in cancer research.

If you would like to attend this seminar, please contact us to arrange site access - seminars@babraham.ac.uk
 

Event Time & Dates

Starts01:00 pm - 09/03/2017
Ends02:00 pm - 09/03/2017

Event Details

ContactDr Heidi Welch
LocationThe Brian Heap Seminar Room
SpeakerProf. Jose Vazquez-Prado
Speaker AffiliationDepartment of Pharmacology, The Center for Research and Advanced Studies of the National Polytechnic Institute (CINVESTAV-IPN) Mexico
Speaker Link

Posted

16 December, 2016