Regulation and dynamics of T cell fateActivated CD4+ T cells have the remarkable ability to differentiate into many different types of effector subsets. This diversification is required for the generation of specialized and pathogen appropriate T cell responses, as well as long-lived and protective memory T cells. Data from our lab have shown distinct influences of antigen affinity and antigen dose on CD4+ T cells responding during infection. How these differences are initiated at the T cell receptor signaling level and translated into diverse cell fates is currently unknown. Although it is widely accepted that heterogeneous T cell differentiation can arise from a single activated T cell, the underlying mechanisms for fate diversification have not been identified. The focus of our work is to understand: how do individual T cells give rise to progeny with such diverse fates? We are using several infection models as well as complementary in vitro microscopy approaches to assess the dynamics and flexibility of T cell differentiation.
If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.
|Starts||01:00 pm - 29/09/2016|
|Ends||02:00 pm - 29/09/2016|
|Contact||Dr Michelle Linterman|
|Location||The Brian Heap Seminar Room|
|Speaker||Dr Carolyn King|
|Speaker Affiliation||ETH Zürich, Basel, Switzerland|
17 August, 2016