Life Sciences Research for Lifelong Health

ILC-fibroblastic reticular cell interaction

Fibroblastic reticular cells (FRCs) of secondary lymphoid organs form distinct niches for interaction with hematopoietic cells. We found that IL-15 production by FRCs is essential for group 1 innate lymphoid cell (ILC1) maintenance in Peyer’s patches and mesenteric lymph nodes. Moreover, FRC-specific abrogation of myeloid differentiation primary response gene 88-dependent innate immune sensing unleashed IL-15 production by FRCs during enteropathogenic virus infection leading to hyperactivation of ILC1 and substantially altered T helper cell differentiation. Accelerated viral clearance by ILC1 precipitated severe intestinal inflammatory disease with commensal dysbiosis, loss of intestinal barrier function and reduced colonization resistance. In sum, FRCs act as “on-demand” immune rheostat by restraining ILC1 activation and thereby preventing immunopathological damage in the intestine.

If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.
 

Event Time & Dates

Starts01:00 pm - 21/10/2016
Ends02:00 pm - 21/10/2016

Event Details

Contact Dr Michelle Linterman
LocationThe Brian Heap Seminar Room
SpeakerProf. Burkhard Ludewig
Speaker AffiliationInstitute of Immunobiology, Kantonsspital St. Gallen, Switzerland

Posted

10 August, 2016