Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modificationsMethylation of cytosine deoxynucleotides is a well-established epigenetic mark, but in higher eukaryotes much less is known about modifications affecting other deoxynucleotides. We report the detection of N-6-methyl-deoxyadenosine in vertebrate DNA, such as frogs, but also in other species including mouse and human. Our methylome analysis reveals that dA6m is widely distributed across the eukaryotic genome, is present in different cell types, but commonly depleted from gene exons. Thus, direct DNA modifications might be more widespread than previously thought.
If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.
|Starts||01:00 pm - 08/07/2016|
|Ends||02:00 pm - 08/07/2016|
|Contact||Prof Wolf Reik|
|Location||The Brian Heap Seminar Room|
|Speaker||Dr Magdalena J Koziol|
|Speaker Affiliation||Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge|
16 May, 2016