Life Sciences Research for Lifelong Health

Identification of methylated deoxyadenosines in vertebrates reveals diversity in DNA modifications

Methylation of cytosine deoxynucleotides is a well-established epigenetic mark, but in higher eukaryotes much less is known about modifications affecting other deoxynucleotides. We report the detection of N-6-methyl-deoxyadenosine in vertebrate DNA, such as frogs, but also in other species including mouse and human. Our methylome analysis reveals that dA6m is widely distributed across the eukaryotic genome, is present in different cell types, but commonly depleted from gene exons. Thus, direct DNA modifications might be more widespread than previously thought.

If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.

Event Time & Dates

Starts01:00 pm - 08/07/2016
Ends02:00 pm - 08/07/2016

Event Details

Contact Prof Wolf Reik
LocationThe Brian Heap Seminar Room
SpeakerDr Magdalena J Koziol
Speaker AffiliationWellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge

Posted

16 May, 2016