CD4 T cell help for humoral immunity in transplantation
In clinical transplantation the development of class-switched humoral immunity directed against either donor alloantigen or autoantigen is increasingly associated with early allograft failure. MHC alloantigen is a classical T-dependent antigen, and our work has focused on how CD4 T cell help is provided for generating destructive antibody responses directed against transplant antigen. In this seminar, I will provide an overview of our recent studies of murine transplant models, which have revealed novel aspects of the cognate interaction between CD4 T cells and B cells. Our findings suggest that the concept of ‘linked’ help is not as robust as previously proposed, that different helper T cell populations may be responsible for maintaining germinal centre responses than for their initiation, and that ‘peptide-degenerate’ recognition of MHC class II complexes on the B cell surface triggers global activation of all B cells. I’m therefore hopeful that our findings will be of interest to non-transplant B cell immunologists and generate productive discussion.
If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.
|Starts||04:00 pm - 22/02/2016|
|Ends||05:00 pm - 22/02/2016|
|Contact||Dr Martin Turner|
|Location||The Brian Heap Seminar Room|
|Speaker||Dr Gavin Pettigrew|
|Speaker Affiliation||Department of Surgery, School of Clinical Medicine, University of Cambridge|
11 January, 2016