Life Sciences Research for Lifelong Health

Deciphering the CD4+ T cell compartment in follicular lymphoma

Follicular lymphoma (FL) is the most frequent indolent lymphoma and results from the malignant transformation of germinal centre B cells in secondary lymphoid organs. Beside the genetic alterations associated with the deregulation of the anti-apoptotic protein Bcl2, the growth of malignant FL B cells relies on the development of a supportive microenvironment, which forms a specialized cell niche contributing to disease development, progression, and drug resistance. Several studies showed that malignant FL B cells are found admixed to specific immune cell subsets, in particular CD4+ T cells. In addition, the nature and the localization of T cells were associated with prognosis. This suggests that different functional CD4+ T cell subsets could play an important role in FL pathogenesis. Based on this hypothesis, we decided to explore the CD4+ T cell compartment found in close contact with FL B cells in malignant lymph nodes and demonstrated a high frequency of follicular regulatory and follicular helper T cells with specific features. These CD4+ T cell subsets emerge as a central therapeutic target, and evaluation of the proportion of these cells would be useful to better predict the biological effect of new drugs.

 
If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.

Event Time & Dates

Starts01:00 pm - 15/03/2016
Ends02:00 pm - 15/03/2016

Event Details

Contact Dr Michelle Linterman
LocationThe Brian Heap Seminar Room
SpeakerDr Patricia Amé-Thomas
Speaker AffiliationUniversity of Rennes, France

Posted

3 November, 2015