Regulation of X-linked genes expression by chromosome conformation in C. elegansAnimal sex is determined by the number of X chromosomes in many species, creating unequal gene dosage (aneuploidy) between sexes. Dosage Compensation mechanisms equalize this dosage difference by regulating X-linked gene expression. In the nematode C. elegans the current model suggests that DC is achieved by a two-fold transcriptional downregulation in hermaphrodites mediated by the Dosage Compensation Complex (DCC, which restricts access to RNA Polymerase II by an unknown mechanism. Taking a nuclear organization point of view, we showed that the male X chromosome resides in the pore proximal subnuclear compartment whereas the DCC bound to the X, inhibits this spatial organization in the hermaphrodites. This led us to propose an updated model of dosage compensation that reassigns the role of DCC from repression of genes to inhibition of activation. Data supporting this model will be presented.
If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.
|Starts||01:00 pm - 15/09/2015|
|Ends||02:00 pm - 15/09/2015|
|Contact||Dr Olivia Casanueva|
|Location||The Brian Heap Seminar Room|
|Speaker||Dr Peter Meister|
|Speaker Affiliation||Institute of Cell Biology, University of Bern, Switzerland|
10 August, 2015