Regulation of the pro-apoptotic BH3-only protein BimBIM is a pro-apoptotic BH3-only protein that induces the ‘Bcl-2-regulated’ apoptotic pathway in response to various stimuli, including DNA damage, cytokine deprivation and several anti-cancer drugs. Accordingly, loss of Bim facilitates development of autoimmunity, neurodegenerative diseases and cancers.
Since Bim can be activated by a plethora of different stress signals, Bim expression must underlie tight regulation to ensure normal cell development and homeostasis. Several transcriptional, post-transcriptional and post-translational regulatory mechanisms have been described over the past years but only a few have been verified in a physiological context.
We generated data that refute a role of the previously accepted transcription factor FOXO3a in the regulation of Bim in the hematopoietic system.
Furthermore, we used reporter-based assays that led to the identification of a CCCH Zinc finger protein as a potential novel post-transcriptional regulator of Bim. Lastly, we found that growth factor-mediated post-translational regulation of BIM facilitates resistance to anti-cancer drugs in human melanoma cell lines expressing the activating mutant form of B-Raf.
Understanding underlying molecular processes of Bim regulation will enable us to improve treatment strategies for diseases that are caused by deregulated Bim.
If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.
|Starts||03:00 pm - 16/06/2015|
|Ends||04:00 pm - 16/06/2015|
|Contact||Dr Martin Turner|
|Location||The Brian Heap Seminar Room|
|Speaker||Dr Leona Rohrbeck|
|Speaker Affiliation||The Walter and Eliza Hall Institute (WEHI) AUSTRALIA|
4 June, 2015