Unraveling the unexpected roles of primase-polymerases in genome replication and repair
To counteract DNA damage and maintain genome stability, cells have evolved a myriad of strategies for repairing and bypassing specific genetic lesions. This seminar will explore our current understand of how, potentially lethal, DNA double-strand breaks are repaired and describe the mechanisms employed by the cellular end-joining apparatus to co-ordinate this process. He will also discuss how studies on DNA break repair polymerases led to the identification of distinct damage tolerance primase-polymerases (PrimPols) that assist DNA replication, defining novel lesion bypass pathways that maintain genome stability in response to replicative stress in cells.
If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.
|Starts||01:00 pm - 14/07/2015|
|Ends||02:00 pm - 14/07/2015|
|Contact||Dr Patrick Varga-Weisz|
|Location||The Brian Heap Seminar Room|
|Speaker||Prof. Aidan Doherty|
|Speaker Affiliation||Genome Damage and Stability Centre, University of Sussex|
14 May, 2015