Life Sciences Research for Lifelong Health

Transgenerational epigenetic inheritance and RNAe

Since August Weismann (1834-1914) formulated the distinction between innate and acquired characteristics at the end of the 19th century, the debate relating to the inheritance of acquired traits has raised many controversies in the scientific community. Following convincing arguments against (e.g. William Bateson) this debate was then set aside by the majority of the scientific community. However, a number of epigenetic phenomena involving RNA, histone modification or DNA methylation in many organisms have renewed interest in this area. Transgenerational effects likely have wide-ranging implications for human health, biological adaptation and evolution, however their mechanism and biology remain poorly understood. We recently demonstrated that a germline nuclear small RNA/chromatin pathway can maintain epi-allelic inheritance for many generations in C. elegans. This is a first in animals. We named this phenomenon RNA-induced epigenetic silencing (RNAe). We are currently further characterizing the mechanism of RNAe. In addition, we are testing the hypothesis that RNAe provides a transgenerational memory of the environment (“Lamarckism”). We are currently exploring related phenomena in mice. We are also working towards establishing iPS cells differentiating into germ cells as a model to study the mechanism of transgenerational epigenetic inheritance.

 
If you would like to attend this seminar, please use the "Contact us" link below to express interest and arrange site access.

Event Time & Dates

Starts01:00 pm - 02/04/2015
Ends02:00 pm - 02/04/2015

Event Details

Contact Dr Olivia Casanueva
LocationThe Brian Heap Seminar Room
SpeakerProf. Eric Miska
Speaker AffiliationWellcome Trust/Cancer Research UK Gurdon Institute
Speaker Linkhttp://ericmiskalab.org/

Posted

9 March, 2015