Life Sciences Research for Lifelong Health

Workshop

GENiE Workshop - Programme

April 19th

12:00 - 13:10: Arrival, registration and lunch

13:10 - 13:20: Welcome and Practicalities

13:20 - 13:40: C. elegans metabolomics (Reuben Smith)
13:40 - 14:00: Predictive genetics with FBA in C. elegans (Toon Santermans)
14:00 - 14:20: A systems view on the impact of the mitochondrial prohibitin complex, a context-dependent mediator of longevity, in the C. elegans metabolome (Artur Bastos Lorenco)
14:20 - 14:40: Characterising a core metabolic enzyme responsible for phosphine resistance and fundamental metabolic regulation with systems biology and genome-scale modelling (Horst Joachim Schirra)
14:40 - 15:00: Optimal environmental growth-control (Benjamin Towbin)

15:00 - 15:30: Coffee Break

15:30 - 15:45: Creating consensus metabolic networks: Best practices and useful tools (Paul Dobson, remotely)
15:45 - 16:20: Progress in merging and reconciling two C. elegans reconstructions (Hooman Hefzi, joined remotely by Nathan Lewis)
16:20 - 16:40: Exploring the metabolic potential of the C. elegans native microbiome (Johannes Zimmerman)

16:40 - 17:00: Short Break

17.00 - 17:20: Defining the media chemically and the E. coli genetically in C. elegans ageing experiments (David Weinkove)
17:20 - 17:40: Deletion of gene coding for mitochondrial citrate carrier in C. elegans impairs the acetylcholine synthesis (Pascale Scarcia)
17:40 - 18:00: Using C. elegans to investigate natural variation in Alzheimer’s disease and related protein mis-folding diseases (Nell Nie)

18:30 Bus collection from Babraham

From ~19:30 till late: Workshop Dinner at Christ's College, Cambridge
 

April 20th

9:00 - 9:20: Introduction to Flux Balance Analysis, Flux Variability Analysis and Pathway Analysis using Whole-Genome Metabolic Models
9:20 - 10:00: Omics data analysis and interpretation using ElegCyc (Christoph Kaleta)

10:00 - 10:30: Coffee Break

10:30 - 11:10: Metabolomics approaches to close gaps on known pathways and description of novel pathways (Michael Witting)
11:10 - 11:30: Missing pathway prioritisation for follow-up annotation jamboree workshop (General discussion)

11:30 - 11:45: Short Break

11:45 - 12:15: Round table on publication of workshop outcomes, future collaboration strategies and opportunities (General discussion)

12:15: Lunch

13:30 - 15:30: TWO PARALLEL PRACTICAL SESSIONS:
Session A - Using ElegCyc and COBRApy: Hands on tutorial (Johannes Zimmerman)
Session B - Metabolite Identification Resources and Quantification Strategies: Tutorial (Michael Witting)
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