19th and 20th April 2017Of the five attributes that define life - motility, growth, excitability, reproduction and metabolism - metabolism is the most essential since it supplies the energy and substances needed for all the others. Although studied for centuries, our knowledge of metabolism is still incomplete. A premier model organism for the study of metabolism is the small roundworm Caenorhabditis elegans, which facilitates studying the relationship between nutrition, gene expression, metabolism and phenotypic traits.
Recently, the first two reconstructions of C. elegans metabolism were published. These reconstructions contain whole-genome maps of interrelated reactions and metabolites, serving as blueprints of C. elegans metabolism and laying the foundation for further research. The first reconstruction, iCEL1273, contains 1985 metabolic reactions and 887 compounds, while the other reconstruction, ElegCyc, contains 1914 reactions and 1640 compounds. It is not yet clear to which extent the two reconstructions overlap. Parallel to these two published versions, other groups have been working on their own reconstructions.
The objective of this workshop is to determine the current state in C. elegans metabolism research and how different metabolic reconstructions, published and non-published, can be integrated in a community-driven effort leading to a comprehensive consensus C. elegans metabolic reconstruction. Within the workshop, researchers from both 'wet-lab' and 'dry-lab' contexts will exchange knowledge and experiences, sharing insights into how different types of data can be integrated using metabolic reconstructions.
Special attention will be given to the integration of -omics data, e.g. transcriptomics, proteomics and metabolomics, and to expanding the consensus metabolic reconstruction beyond gene annotations towards integration with ChEBI or WormBase and other Alliance of Genomic Resources Databases through the use of common standards.
We will also discuss future jamboree sessions on specific topics identified during this workshop, such as the annotation of specific metabolic pathways that are of particular interest to the community to further improve the quality of the C. elegans metabolic reconstruction.
This workshop is open to all researchers with an interest in C.elegans metabolomics and is not limited to GENiE consortium members. There are a limited number of places available, please register using the link on the left.
The first day of the workshop will include scientific sessions during which participants are encouraged to present their current work on C.elegans metabolism, metabolic reconstruction or metabolomics.The full programme for the workshop can be found here.
Talks will be 15 minutes with 10 minutes of Q&A - to submit an abstract, please follow the link to the registration page.